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Development of a scoping review to consider how to trigger or waiver the TG 305 (bioaccumulation in fish test) for manufactured nanomaterials - CB04109

Description
Defra will provide policy direction and oversight to the University of Plymouth as the delivery body. The University of Plymouth will be responsible for the delivery of key milestones, coordinating the expert group, leading the drafting of a questionnaire, delivering workshops as required and drafting the final scoping review document for submission to the WPMN. The Defra team will provide input and direction where required and will also join the ad hoc OECD expert group assigned to support this project. University of Plymouth will provide additional support in the 20/21 financial year to respond to an OECD review of the draft scoping document and to re-draft it as required with support from Defra and wider government colleagues.

NanoHarmony will provide financial leverage in terms of staff time to process existing data and scientific evidence to support the rationale for the scoping review as it develops. Also, fund any ‘gap filling’ tasks that might need the collection of new experimental data in the laboratory. NanoHarmony will also make a more detailed meta-analysis of existing data sets to support the scoping review by revisiting the substantial data archive held at the University of Plymouth as part of the NanoHarmony project. NanoHarmony will also offer additional meetings and workshops of the experts to ensure the timely development of the science and its application to the OECD process. NanoHarmony will host expert workshops on the 3-5 November 2020, and annually in April 2021, in addition to teleconferences, delivered by the University of Plymouth. This will add critical mass to the consensus building that Defra will need to take forward the UK’s proposal at the OECD. The NanoHarmony timeline is also planned to map onto the OECD process and the UK involvement at the OECD, so that NanoHarmony facilitates access to the science as it is needed for policy and regulatory decision-making.
Objective
The objective of this project is therefore to undertake the development of a scoping review with the following content:

1. Background of TG 305 and its use in different regulatory frameworks for bioaccumulation assessment of nanomaterials
2. Benefits of being able to trigger or waive TG 305 in terms of animal welfare and potential cost-savings and considering the importance of chemical safety
3. An overview of available tests currently available that could be used to determine if TG 305 can be trigger or waived
4. Evidence of correlations between lower tier tests and TG 305 to ensure results are providing accurate estimates of NM bioaccumulation
5. Working Party on Manufactured Nanomaterials Recommendations will be formulated with next steps in developing tools or guidance to support decision making in triggering or waiving TG 305 for nanomaterials.

Time-Scale and Cost
From: 2020

To: 2021

Cost: £77,869
Contractor / Funded Organisations
University of Plymouth
Keywords
Animals              
Environmental Protection              
Fields of Study
Chemicals and Nanotechnology