Defra - Department for Environment, Food and Rural Affairs.

Science Search

Science and Research Projects

Return to Science Search homepage   Return to Project List

Biochemistry and genetics of anticoagulent resistance in rodents (Joint with PSD - PV0202) - VC0302

Description
VC0302. Biochemistry and genetics of anticoagulant resistance in rodents.

Previous research has suggested that a number of genes regulating detoxification mechanisms in rats are involved in resistance to second generation anticoagulant pesticides such as difenacoum. This study will investigate the following hypothesis: whether difenacoum resistance in rats is a polygenic trait, and whether rats showing this trait are likely to be cross-resistant to other vertebrate pesticides. The study will be composed of the following 3 objectives: 1. To determine the role of increased anticoagulant metabolism and detoxification in resistance to second generation anticoagulants; 2. To investigate whether increased detoxification mechanisms may result in tolerance to other heterocyclic chemicals that may be used as rodenticides; and 3. To examine the polygenic nature of resistance to anticoagulants, and whether that is related to changes in detoxification mechanisms. Results of the study should identify whether or not co-selection of tolerance to potential new rodenticides is a problem. If the hypothesis is correct then all proposed rodenticides must be tested against all of the appropriate strains. Overall results and conclusions from the study will be communicated via technical literature and the advisory services to the agricultural and pest control industries; detailed scientific results will be published in scientific journals.
Objective
To determine the role of increased anticoagulant metabolism and detoxification in resistance to second generation anticoagulants. To investigate whether increased detoxification mechanisms may result in tolerance to other heterocyclic chemicals that may be used as rodenticides. To examine the polygenic nature of resistance to anticoagulants, and whether that is related to changes in detoxification mechanisms.
Time-Scale and Cost
From: 1993

To: 1995

Cost: £335,000
Contractor / Funded Organisations
Central Science Laboratory
Keywords
              
Fields of Study
Wildlife Management