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The Influence of Antioxidant Nutrients and Free Radicals on Platelet Function in Man - AN0411

The aims are to investigate whether antioxidant nutrient supplementation in humans in vivo influences platelet function and thus exerts a role in maintaining health and preventing disease. We shall study the relationship between in vivo levels of antioxidant nutrients and the predisposition of platelets to aggregate. The correlation between the specific dosage of antioxidant nutrients and recovery in vivo in plasma, LDL and in platelets of specific individuals will be monitored by undertaking a small initial pilot study of 32 individuals, supplementing with alpha-tocopherol, ascorbate and beta-carotene, initially separately and subsquently in combination. The results will allow monitoring of the bioavailability of antioxidant nutrients in vivo in comparison with the intake level.
1. To assay the endogenous levels of antioxidants in vivo, in plasma, LDL and platelets of volunteers in order to establish the relationship of antioxidant levels in different volunteers with platelet function and the tendency for the platelets to aggregate, 2. To establish the value of supplementation with antioxidant nutrients.
Time-Scale and Cost
From: 1993

To: 1996

Cost: £141,802
Contractor / Funded Organisations
United Med&Dental Sch. Free Radical Res.