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Dietary Antioxidants and Endothelium-dependent Vasodilation: Prevention of Vascular Dysfunction - AN0410

The study will investigate whether dietary antioxidants have a protective effect on the human artery wall. an important indicator of arterial disease is the impairment of vasodilation. Vasodilation occurs as a result of release of nitric oxide from the endothelium. The purpose of this project is to investigate the effects of antioxidants on this process. Firstly the effects will be studied using cultured endothelial cells. Secondly forearm blood flow measurements will be made on individuals with moderate hyperlipidaemia before and after receiving dietary advice and again after supplementation with vitamin E or vitamin C.
1. To evaluate the effects of native and oxidised LDL directly on the synthesis of nitric oxide by endothelial cells. To study the effects of water and fat-soluble antioxidants alone on this process and in the presence of lipoproteins. To determine the mechanism of these effects. 2. To study the effects of dietary advice and antioxidant supplementation on the potency of the vascular endothelium using a test if forearm blood flow and relating this to plasma lipoprotein profile and susceptibility of LDL to oxidation.
Time-Scale and Cost
From: 1993

To: 1996

Cost: £139,830
Contractor / Funded Organisations
Royal Free Hospital School of Medicine