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Investigations into the determinants of Mareks disease virus pathogenicity for developing novel molecularly-defined attenuated vaccines - OD0719

Description
Marek's disease (MD) is one of the most important disease affecting poultry health and welfare, with huge economic losses to the poultry industry. DEFRA-funded research project OD0718 that is due to end in June 2009 has made significant progress understanding the molecular determinants of some of the important aspects of this disease. The current proposal is to continue this research to make further progress in our knowledge of this disease that will help to develop long-term sustainable control strategies. The research proposed project fulfils the DEFRA requirements under Alternatives to pharmaceutical control of endemic animal disease (Requirements 36-38) on Control of MD, an area of research identified as significantly important by the Poultry Research Committee.

Objective
Specific objectives

1. Functional evaluation of of viral genes directly linked to Marek's disease pathogenicity using mutagenesis strategies on infectious clones of virulent strains of the virus

2. Evaluation of in vitro and in vivo replication of specific mutant viruses for their potential as novel vaccines

3. Examination of the dynamics of MDV replication and shedding from the feather follicle epithelium of infected birds
Project Documents
• EXE - Executive Summary : OD0719 Summary Report   (117k)
Time-Scale and Cost
From: 2009

To: 2012

Cost: £562,552
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Health              
Marek's              
Plants and Animals              
Poultry              
Vaccine Development              
Vaccines              
Veterinary Medicines              
Fields of Study
Animal Health