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Evolution of multidrug resistance in Salmonella enterica serovar Typhimurium as a result of biocide exposure. - OD2029

Defra project OD2010 found that exposure of S. Typhimurium to sub-lethal concentrations of disinfectants can result in mutations that confer resistance to antibiotics. OD2029 will aim to identify how quickly such resistance develops and the fitness of such strains. This information will be of value in determining the risk of inappropriate use of disinfectants, and may help inform best practice in this area.

A second objective will determine whether development of multiple drug resistance (MDR) as a result of biocide stress can occur independently of loss of virulence or whether MDR and virulence are genetically linked.

The proposed work will also take forward the analysis of antibiotic resistant mutants by comparing genotype, phenotype and transcriptome. It is envisaged that the combination of these state-of-the-art techniques will allow identification of mutants involved in biocide resistance and function, and may lead to identification of novel antimicrobial targets.
Time-Scale and Cost
From: 2009

To: 2012

Cost: £495,828
Contractor / Funded Organisations
BBSRC Central Office
Animal Health              
Antimicrobial Resistance              
Plants and Animals              
Veterinary Medicines              
Fields of Study
Animal Health