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Use of National Poisons Information Service (NPIS) systems to monitor adverse health effects of pesticides and biocides in the UK population - PS2617

When pesticides and industrial chemicals are used by human populations adverse health effects may result from a number of different scenarios, but especially as a result of inadvertent exposure, or accidental and deliberate ingestion. When new products are introduced their potential for adverse effects on human health are assessed on the basis of work generally performed in laboratory animal models, on occasion supported by data from experimental human exposure studies. The purposes of the ongoing project are: to identify the nature of, and causative factors for, adverse health effects of pesticides predominantly following acute exposure. The present proposal is an extension of existing work which has been on going for the past 4 years and which has been targeted at a specific group of pesticides and their health effects. That work has shown that the approach used is possible, able to produce valuable epidemiological data, and can inform regulators and health care professionals of the acute health effects of pesticides using exposure data reported to the NPIS.

This proposal will build on experience gained in the existing NPIS study funded by DEFRA, which captures information on exposures as reflected in on line enquiries to the NPIS via its TOXBASE website. TOXBASE is presently used to identify index cases, and information on the case itself either collected up directly online or followed up by questionnaire.

The new project will further develop and expand the existing approach in three ways. Firstly by using the new enhanced TOXBASE platform to improve data capture and hence increase immediate feedback and improve follow-up rates. Secondly to apply the UK-wide NPIS telephone database UKPID to capture all UK NPIS telephone inquiries on products of interest. Thirdly to enhance TOXBASE to emphasise the importance and of data on exposures during pregnancy and further utilise the expertise of the NPIS sister service, the National Teratology Information Service (NTIS) to capture more cases of pregnancy exposure from pesticides. This will include all occupational exposures about which the NPIS are called. The objectives of this expansion of to establish the utility of NPIS methodologies for collecting health information of this type and to estimate systematically the health burden placed upon the NHS by pesticide and biocide exposures.Overall this study will improve monitoring of the health effects of a variety of pesticides and biocides in people who have been exposed in a manner which results in contact with the National Poisons Information Service (NPIS) and its associated National Teratology Information service (NTIS).
1.Identify those pesticide and biocides associated with ill health following human exposure from enquiries to NPIS at a UK National level by TOXBASE and telephone enquiry (4500 TOXBASE +1000 telephone enquiries)

2. Inform regulators on the utility of more systematic NPIS data collection of pesticide and biocide exposure data in surveillance, product safety and health prevention strategies.
Time-Scale and Cost
From: 2009

To: 2017

Cost: £670,255
Contractor / Funded Organisations
National Poisons Information Service
Hazardous substances              
Pesticide use              
Public Health              
Fields of Study
Pesticide Safety