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International Conference on Extended-Spectrum Beta-Lactamases (ESBLs); Veterinary Relevance and Public Health Aspects - OD2027

Description
This proposal concerns the staging of a one day international conference on extended-spectrum beta-lactamases (ESBLs), their significance in animals and their public health importance. ESBLs are enzymes produced by certain bacteria which inactivate a wide range of penicillin and cephalosporin compounds and therefore comprise a very important mechanism of antimicrobial resistance. In recent years, a number of different types of ESBLs have been identified in humans and animals in different parts of the world and some of these have been associated with serious human infections. The general trend in human medicine is of an increasing prevalence, importance and clinical relevance of this type of resistance particularly in conditions such as urinary tract infection.

ESBLs have recently been detected in several European countries in animals particularly in Salmonella spp. and in Escherichia coli. Most reports in animals relate to the presence of ESBLs in bacteria in food-producing animals, though there have also been reports of ESBLs in bacteria recovered from companion animals (dogs and cats) and from horses.

The conference will concentrate on the developing and evolving situation in livestock and humans in Europe and the possible relevance of ESBLs in bacteria in animals to public and animal health. The main focus of the conference will be on food-producing animals; the food chain will also be considered, as well as the developing global situation in humans, particularly in Asia and the Far-East. As well as describing the current prevalence of ESBLs in livestock and humans in Europe and elsewhere, the conference will also consider any control measures that may have been applied. Time constraints will unfortunately mean that only limited time can be spent on some aspects. ESBLs may exist in the commensal bacteria in the gut of humans and animals and in those circumstances control, other than the obvious measure of reducing the selective pressure exerted by using cephalosporin and penicillin antimicrobials, is problematic, particularly since commensal bacteria such as E. coli may exist for a considerable period outside the host or be transferred by suitable vectors to other environmental niches. Control options will however, be highlighted wherever possible during the conference.

Current findings relating to the molecular organisation of ESBLs will be reviewed and the potential for this information to be used in tracking the spread and development of ESBLs discussed.

In summary, the conference will aim to:
-review the current situation regarding ESBLs in humans and food-producing animals in several European countries, as well as in selected other parts of the world.
-provide an update regarding the current situation in the UK in food-producing species for debate amongst the assembled experts.
-consider recent findings relating to companion animals and horses.
-consider recent developments regarding the molecular genetics of ESBLs in bacteria.

Expert speakers, from the UK, Europe and elsewhere will be asked to contribute to the meeting.

Presentations will be summarised in a book of conference proceedings; if speakers are in agreement, proceedings will also be published on the VLA/ Defra web-sites.
Objective
The overall objective of this proposal is to stage an international conference on ESBLs, bringing together veterinarians, medical practitioners and researchers from Europe and elsewhere to discuss the latest findings in this area, with particular emphasis on veterinary aspects.

There will be a number of secondary objectives, some of which will be covered in greater detail than others, because of the time constraints necessarily imposed by holding the meeting on one day. These will include:

1) Reviewing the current situation regarding ESBLs carried by bacteria in humans and food-producing animals in several European countries and elsewhere, including prevalence of resistance, types of ESBLs encountered, surveillance programmes and control measures.

2) Providing an update regarding the current situation in the UK in food-producing species for debate amongst the assembled experts.

3) Discussion of molecular aspects, particularly with regard to the approaches that should be taken at the European level to identify and characterise strains and recent developments regarding the molecular genetics of ESBLs in bacteria.

4) Other aspects, such as recent findings relating to companion animals and horses will be discussed as far as time constraints allow.

Presentations will be summarised in a book of conference proceedings; if speakers are in agreement, proceedings will also be published on the VLA/ Defra web-sites.
Project Documents
• Final Report : International Conference on Extended-Spectrum Beta-Lactamases (ESBLs); Veterinary Relevance and Public Health Aspects   (2877k)
Time-Scale and Cost
From: 2007

To: 2008

Cost: £12,409
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Antimicrobial Resistance              
Bacteria              
E.coli              
Health              
Plants and Animals              
Veterinary Surveillance              
Fields of Study
Animal Health