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A study to identify physicochemical factors controlling the capacity of nanoparticles to penetrate cells of the respiratory epithelium, especially those of first contact on inhalation of the particles - CB0405

Description
As nanotechnology is moving fast it is important to determine whether they might be toxic, or have unwanted effects on health, so that we can protect people and the environment from exposure. The aim is to discover how, when inhaled engineered nanoparticles reach the delicate air sacs of the lung, they interact with the cell barriers that protect us. Thus, we will investigate epithelial cells that line human lungs. These cells will be exposed to nanoparticles which have different surface properties to discover whether the nanoparticles interact with and/or are internalised by the cells. We want to know what properties of the particles might make them reactive - do they pass into the cells, or between the cells or are any particular surface characteristics responsible for nanoparticle toxicity? What cellular processes, or cellular secretions, are involved? We will use unique microscopic techniques to watch nanoparticles under the microscope to monitor and see how they alter cell behaviour. If we discover that some properties of these flourescent nanoparticles might be harmful, we can investigate other engineered nanoparticles whose use is increasing to discover whether they have similar properties and whether it is possible to make them safer.
Project Documents
• FRP - Final Report : A Study to identify physicochemical factors controlling the capacity of nanoparticles to penetrate cells of the respiratory epithelium, especially those of first contact on inhalation of the particles   (792k)
Time-Scale and Cost
From: 2007

To: 2008

Cost: £36,949
Contractor / Funded Organisations
The Imperial College of Science Technology and Medicine
Keywords
Chemicals              
Environmental Protection              
Pollution              
Fields of Study
Chemicals and Nanotechnology