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Development of analytical strategies for rapid low cost analysis of pesticide residues in food - PS2519

Description
The purpose of the research is to support the necessary ongoing development of the UK Pesticides Monitoring Programme by providing the Pesticide Residues Committee with robust, rapid and lower cost methods for the analysis of pesticide residues in foods.

The limitations imposed by a combination of rigorous quality control requirements (which limit the number of tests that can be afforded on each sample) and the target compound approach (which limits the scope), inevitably means that residues outside of the current PRC target list may not be detected and the number of multiple residues will be underestimated. As a consequence it is likely that MRL exceedances and cases of misuse may also go undetected and the UK monitoring programme will fail to detect changes to the profile that result from the use of new pesticides or changes in pesticide usage. This may have implications for the accuracy of risk assessments and may potentially undermine public confidence in the PRC monitoring programme.

The determination of pesticide residues by chemical analysis is costly and time consuming and there is a continuing need for the development of rapid low cost, multi-residue methods with broad scope. The objectives of this proposal are:

1) To evaluate deconvolution data handling options and implement the most appropriate option as a means to increase the efficiency of data manipulation and of increasing the number of pesticides included in a single GC-MS screening analysis.

2) To evaluate whether a simplified strategy for AQC is possible for both GC/MS and LC/MS based MRMs (e.g. representative analyte calibrations).

3) To disseminate and explain the findings both to the sponsors and the wider scientific community.





Objective

1) To evaluate deconvolution data handling options for GC/MS and implement the most appropriate option as a means to increase the efficiency of data manipulation and of increasing the number of pesticides included in a single GC-MS screening analysis.

2) To evaluate whether a simplified strategy for AQC is possible for both GC/MS and LC/MS based MRMs (e.g. representative analyte calibrations). To include pilot testing of proposed methodology and AQC approaches against existing approaches in PRC survey work.

3) To generate underpinning data to tailor recommendations on the development of integrated GC and LC multi-residue approaches to ensure PRC future methods achieve an appropriate balance for monitoring purposes in terms of a) sample throughput; b) analysis of a wide range of analytes, including new compounds; and c) fit for purpose analysis and reporting of results (e.g. screening and semi-quantitative/quantitative approaches).

4) To disseminate and explain the findings both to the sponsors and the wider scientific community.
Project Documents
• Final Report : Development of analytical strategies for rapid low cost analysis of pesticide residues in food   (176k)
• Final Report - Annex : Development of analytical strategies for rapid low cost analysis of pesticide residues in food   (243k)
Time-Scale and Cost
From: 2004

To: 2007

Cost: £116,379
Contractor / Funded Organisations
Central Science Laboratory
Keywords
Agriculture and Food Chain              
Analysis              
Analytical Chemistry              
Analytical Quality Control              
Food Quality              
Food Safety              
Pesticide Residues              
Public Health              
Residues Testing              
Fields of Study
Pesticide Safety