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Conformational analysis of prion proteins: Toward an Antemortem Test For Bovine Spongiform Encephalapathy: An Ion Mobility /Mass Spectrometry Approach. - SD0405

A high sensitivity, mass spectrometry, ion mobility based, method has been developed to measure protein cross section. This approach is based on the principle that larger molecules, in the gas phase, take longer to pass through a region containing a low pressure of inert gas molecules than smaller molecules. The misfolding pf prion proteins, which is believed to be the root cause of the development of transmissible spongiform encephalopathies (TSE's), results in a significant increase in cross section. This method has the potential to monitor this misfolding event and thus provide the basis for an antemortem for TSE's.
Project Documents
• Other : Conformational analysis of prion proteins: towards an ante-mortem test for BSE. An ion mobility/mass spectrometry approach   (28k)
Time-Scale and Cost
From: 2005

To: 2009

Cost: £611,927
Contractor / Funded Organisations
University - Warwick
Animal Diseases              
Animal Health              
Animal Welfare              
Mass Spectrometry              
Plants and Animals