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Use and abuse of non-antibiotic antimicrobials as major contributors toward the development of antimicrobial resistance - OD2010

Description
EU legislation on the removal from use of certain antibiotics, and the consequent sensitivity in the farming industry toward a general reduction of antibiotic use in animal husbandry, has prompted the wider use of alternative control practices, such as improved biosecurity, to protect food animals from infection with zoonotic pathogens. Cleansing and disinfection (C&D) regimes are considered important and are used widely for bio-security. Recent studies at VLA and Birmingham have demonstrated that growth of Salmonella enterica serotypes with sub-inhibitory concentrations of triclosan or phenolic farm disinfectants leads to increased occurrence of multiple-antibiotic-resistance (MAR) and gyrA mutants (fluoroquinolone resistance). The objectives of this study are to:- (1) evaluate and review current on-farm practices for the use of non-antibiotic antimicrobial agents, including disinfectants, with particular emphasis upon the poultry industry, (2) model, using appropriate in vitro and in vivo models, the use of a selection of agents and monitor the rise of MAR and fluoroquinolone-resistant mutants particularly, (3) use appropriate molecular tools to define the type and clinical significance of the mutants arising from these studies and (4) provide advice, for policy development, on the risks associated with use and abuse of disinfecting agents in the derivation of bacterial pathogens potentiated for antibiotic resistance. The results of this study will be published in appropriate fora and recommendations made to Defra and other government agencies of the risks associated with inappropriate C&D regimes. This information should inform better farm practice for C&D and thereby reduce the risks of selecting organisms resistant to various antimicrobials, some of which are clinically significant.
Objective
1. Farm practice and association with biocide resistance.
2. Acquisition of biocide resistance and environmental fitness.
3. In vivo fitness (using poultry models) of biocide resistant strains.
4. Phenotypic-genotypic analysis of increased biocide resistance.
Project Documents
• Final Report : Use and abuse of non-antibiotic antimicrobials as major contributors toward the development of antimicrobial resistance   (314k)
• Final Report - Annex : Use and abuse of non-antibiotic antimicrobials as major contributors toward the development of antimicrobial resistance - appendices   (1980k)
Time-Scale and Cost
From: 2003

To: 2007

Cost: £433,925
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Diseases              
Animal Health              
Antimicrobial Resistance              
Disinfection              
Endemic Diseases              
Food Safety              
Poultry              
Public Health              
Veterinary Medicines              
Fields of Study
Animal Health