Defra - Department for Environment, Food and Rural Affairs.

Science Search

Science and Research Projects

Return to Science Search homepage   Return to Project List

Prediction of susceptibility to long-term genotoxic effects of organophosphate pesticide exposure - VM02301

Description
The project aims to:-

investigate the extent, and inter-individual variations in the manifestation, of DNA damage by OPs of diverse chemical structures
elucidate the mechanism(s) involved in the manifestation of the DNA damage
determine inter-individual variations in capacity to repair the damage

indicate the influence of metabolic capacity in balance with the individual’s ability to repair the DNA damage inherent to each OP
These data will provide information which could be used by DEFRA for risk assessment of genotoxicity following chronic exposures to OPs. This research is directly relevant to DEFRA’s mission of protecting public interest in relation to environmental impacts.
Project Documents
• Final Report : Prediction of susceptibility to long-term genotoxic effects of organophosphate pesticide exposure   (433k)
• Executive Summary : Executive Summary   (37k)
Time-Scale and Cost
From: 2003

To: 2007

Cost: £282,141
Contractor / Funded Organisations
University - Newcastle
Keywords
Animal Health              
Organophosphates              
Pesticide use              
Plants and Animals              
Sheep Dipping              
Veterinary Medicines              
Fields of Study
Animal Health
Veterinary Medicine