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Immunological approaches to the control of sheep scab - OD0544

Description
Sheep scab is an allergic dermatitis caused by the mite, Psoroptes ovis. Non-chemical approaches to the control of arthropod ectoparasites are being sought as alternative strategies to insecticidal and acaricidal chemicals which are perceived to be harmful to operator personnel and to the environment, and which will eventually select for resistant strains. Immunopathogenesis studies have demonstrated that sheep acquire strong protective immunity to P. ovis following infection. Furthermore, considerable protection to challenge can be induced by injecting sheep with certain fractions of the mite, the best to date reducing lesion areas and mite numbers by more than four and fifteen-fold, respectively.

The objective of this study is to identify the precise antigens responsible for providing protection against the sheep scab mite and to synthesise these as recombinant proteins so that they can be produced cost-effectively for use in a commercial vaccine
Time-Scale and Cost
From: 2004

To: 2006

Cost: £769,799
Contractor / Funded Organisations
Central Science Laboratory
Keywords
Animal Diseases              
Animal Health              
Animal Welfare              
Endemic Diseases              
Farming              
Livestock Farming              
Parisitology              
Sheep              
Sheep Scab              
Vaccine Development              
Veterinary Medicines              
Fields of Study
Animal Health