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Investigation of gastrointestinal effects of organophosphate/carbamate pesticide residues on young children - PS2602

The main objectives of this research are to:
· establish background population distribution for organophosphate and carbamate metabolite levels in urine and faecal samples from young children; and
· establish whether there is a link between pesticide residue exposure and gastrointestinal effects in children and determine what part diet plays in the pesticide residue exposure.

The proposal has been designed to have sufficient statistical power to enable an opinion to be given on whether there is any relationship between pesticide exposure and gastrointestinal effects. Such an outcome will directly address concerns raised by the Committee on Toxicity and special interest groups. It will enable DEFRA to provide suitable, science-based, guidance to consumers. This proposal follows on from a successful pilot study (PR1146) undertaken by HSL which demonstrated that the approach presented here is feasible. The proposal has taken note of suggestions from DEFRA and the MedTox panel with regard to some of the issues raised by the pilot study. The results of the study will be presented to DEFRA and disseminated in the public domain via appropriate routes.
1. Project set up
Questionnaires, a database, sample kits and information will be prepared. Ethics Committee approval will be sought from South Sheffield Research Ethics Committee.

2. Recruit and maintain sample populations
Parents with children aged 1 to 4 years will be recruited from departments at Sheffield Children’s Hospital and Doncaster Royal Infirmary. Children will be followed up by hospital staff and will provide samples of urine and faeces, twice when well and once when suffering from gastrointestinal effects. Approximately 100 samples are required for the symptomatic group, this will result in 200 baseline samples being collected.

3. Sample analysis
Samples will be analysed by HSL for OP/C pesticide metabolites using previously reported methods. Faecal samples will also be tested for rotavirus (the most common cause of GI effects in young children) to determine viral infection.

4. Data analysis and report
Correlation between pesticide levels, symptoms and diet will be examined. An opinion will be presented as to the likelihood of dietary pesticide residues causing gastrointestinal effects. Background population ranges will be determined for the analytes monitored.
Project Documents
• Final Report - SID5 : Investigation of gastrointestinal effects of organophosphate/carbarnate pesticide residues on young children   (2017k)
Time-Scale and Cost
From: 2004

To: 2007

Cost: £217,631
Contractor / Funded Organisations
Health & Safety Laboratory
Food Quality              
Hazardous substances              
Mass Spectrometry              
Pesticide Residues              
Pesticide use              
Public Health              
Fields of Study
Pesticide Safety