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The effect of rendering on TSE agent strain type - SE0234

The aim of this proposal is to study the effects of the rendering process, as simulated in a laboratory scale version of the Carver-Greenfield process developed under SE0229, on the characteristics of selected strains of TSE agent by bioassay typing in mouse panels.

Materials to be rendered will be selected through discussion with TSERSU. For the purposes of this proposal BSE-infected bovine brain, BSE-infected ovine brain, 301V infected murine brain and a 4th murine passaged scrapie strain will be utilised.

MAFF, in their 2001 / 2002 TSE Research Requirements document para. 3.1, require to determine if rendering can alter the phenotype of BSE or scrapie. The facilities for selective rendering and subsequent mouse bioassay capacity at VLA-Weybridge, offer the facilities and expertise to progress a staged study of rendering effects on individual strains of agent and then on mixtures of strains (para. 3.2) with particular reference to the differential inactivation of BSE and scrapie.
Project Documents
• Final Report : The effect of rendering on TSE agent strain type   (1692k)
Time-Scale and Cost
From: 2001

To: 2007

Cost: £235,115
Contractor / Funded Organisations
Veterinary Laboratories Agency
Animal Health              
Plants and Animals              
Fields of Study
Animal Health