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Immunological control of coccidial infection - OD0543

Description
The first objective of this project will be to determine the cellular nature of the immunoprotective response is esstential and will indicate which parts of the host immune response need to be targeted during the rational developement of the next generation of anti-coccidial vaccine strategies. WE propose to apply our new technique for adoptive transfer of lymphocytes between immune and naive chickens to examine the effector cell subsets that control E. maxima infection in the chicken. This approach represents a major advance in the study of avian immunology since we can now examine the effective anti-pathogen responses rather than measuring all of the responses induced by infection. It is a technology that has been driven by our previous and ongoing work with the murine/E vermiformis system.
Antigenic diversity within some Eimeria spp. has major implications for vaccine development and the second objective of this project will be to examine the interrelationship between host and parasite genetics that govern the development of broad strain-cross-reactive immune protection. This information will help to define how many antigenic determinants have to be included in a vaccine to protect all the genetically diverse UK flock from disease. The studies with Eimeria spp. also impact on the general understanding of gut immune responses, which are particularly relevant to the generic design of oral vaccination strategies.
The work included in this proposal addressess DEFRA key policy objectives including;
1. A contemppporary approach towards th edevelopment of novel immunlogical strategies for sustainable control of coccidial disease.
2. Research to circumvent the need for the high lvel of prophylactic chemotherapy currently required to control disease (240 tonnes/annum in the UK) - thus reducing the prospects for drug-residues in meat for human consumption.
3. Research on a group of diseases that are of immense importance in terms of farm econmics and animal welfare.
4. To develop strategies that promote sustainable farming within the UK.
5. Maintenance, within the UK, of an internationally respected scientific programme that act on behalf of, and respond to requirements of, DEFRA, the consumer and industry,
6. A focus for co-funded research projcts, both directly for control of animal diseases as well as to support research into protozoal zoonoses.
Objective
1. To examine which immune cell types operate to kill avian Eimeria spp. in vivo.
2. To examine the interactions of host and parasite genetics that define antigenic diversity and immune escape of populations of E. maxima.
Project Documents
• Final Report : Final Report SID5   (10242k)
Time-Scale and Cost
From: 2003

To: 2006

Cost: £432,000
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Diseases              
Animal Health              
Biotechnology              
Control              
Parasites              
Plants and Animals              
Poultry              
Vaccines              
Fields of Study
Animal Health