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Innate and vaccine-induced resisance to bovine respiratory pathogens - OD1611

Respiratory infections of livestock are a major animal welfare problem and pose a considerable finicial burden to U.K. agriculture. Outbreaks of respiratory disease can be associated with a single pathogen or may be multifactorial, the result of a secondary bacterial infection following a primary virus infection. Irrespective of the aetiology, treatment of the disease invariably involves the use of antibiotics, which increases the likelihood of the emergence of antibiotic-resistantt organisms, which pose a risk to human health. Infections of the lung are initiated either by inhalation of air-borne organisms or by direct contact with other infected animals leading to infection in the upper respiratory tract with subsequent spread to the lungs. Alveolar macrophages found in the airspaces of the lung respresent a first line of defence against such pathogens and many of the organisms that cause respiratory disease subvert the functions of these cells. These properties of pathogens enable them to establish infection, and also to increaase the susceptability of the respiratory tract to infection with other microorganisms. One such pathogen is bovine respiratory syncytial virus (BRSV), which is a major cause of lower respiratory tract disease in young calves and which appears to predispose animals to supeinfection with other micro-organisms. An effective BRSV vaccine would therefore protect against RSV respiratory disease as well as reducing the incidence of microbial superinfection. Thus, vaccination provides a sustainable means of respiratory disease control. However, the development of effective vaccines against respiratory pathogens based on traditiona, emphirical approaches has had only limited success. Developments in recombinant DNA technology have created new opportunities for vaccine development. The main aims of this project are therefore to utilise BRSV in order to:
(A) Investigate the ways in which BRSV infection may predispose to infection by other pathogens, including Mycobacterium bovis; and
(B) Develop validated methods and standard operating procedures for assessing and predicting the efficacy of candidate respiratory vaccine components and delivery systems.
The result from this study will be of value for the development of a safe and effective vaccine against BRSV and other bovine respiratory pathogens. Effective vaccines against respiratory pathogens will lead to improved animal welfare, provide a cost-effective and sustainable means of controlling respiratory infections and reduce reliance on the use of antibiotics. In addition, evidence that BRSV infection might influence the immune response to M. bovis will have implications for the identification of cattle with turberculosis
01: Analysis of the effect of BRSV infection on alveolar macrophage activity.
02: Characterisation of immune modulation induced by BRSV infection.
03: Characterisation of immune modulation induced by BRSV infection.
04: Vaccine strategies for induction of specific types of immune responses.
Project Documents
• Executive Summary : Innate and vaccine-induced resistance to bovine respiratory pathogens   (29k)
Time-Scale and Cost
From: 2002

To: 2003

Cost: £382,400
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Animal Diseases              
Animal Health              
Bovine Immunology              
GM Non-Food              
Plants and Animals              
Fields of Study
Animal Health