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Markers of avian top predator exposure to oestrogenics - CB01015

Description
The recent review of research on endocrine disruption in top predators conducted for DETR by CSL demonstrated a lack of any reliable marker of exposure or effect for reproductive impacts in avian top predators. There has been little application of vitellogenin (egg yolk protein)this biomarker in birds, although initial studies have shown that injection of oestradiol into male birds dramatically increases plasma vitellogenin concentrations. This project provideS a phased approach to the assessment of the use of direct and indirect vitellogenin assays to monitor the exposure of birds (Japanese quail and cormorant) to oestrogenics and evaluate the correlation of this with brain and gonad aromatase activity and reproductive capacity.

Objectives
To develop robust methods for monitoring vitellogenin levels, brain and gonad aromatase activities in the Japanese quail and cormorant.
To evaluate whether a correlation exists between vitellogenin levels, aromatase activity and reproductive performance in male Japanese quail
Project Documents
• Final Report : Vitellogenin and aromatase as markers of avian top predator exposure to estrogenics   (3005k)
Time-Scale and Cost
From: 2001

To: 2003

Cost: £147,440
Contractor / Funded Organisations
Central Science Laboratory
Keywords
Birds              
Chemicals              
Endocrine Disruptors              
Environmental Protection              
Hazardous substances              
Pollution              
Fields of Study
Chemicals and Nanotechnology