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The Relative Transmissibility of Sheep and Cattle BSE to Humans - SE1439

Description
BSE has been shown to have transmitted from cows to man, whereas there is no evidence that sheep scrapie has transmitted from sheep to man. It is therefore important to establish if BSE is now present in sheep, whether it retains the strain characteristics of BSE in cows that allow it to be transmitted to humans or it has strain characteristics associated with sheep scrapie which does not apparently transmit to man.

This programme aims to compare the relative transmissibility of sheep scrapie and sheep passaged BSE and cattle BSE to human. This will be achieved through titration of cattle BSE, sheep passaged BSE and sheep scrapie in transgenic mice in which the coding region of the endogenous murine PrP gene has been replaced by a bovine, sheep or human PrP gene coding region. This addresses MAFF TSERRD 1.3 and will address the likelihood of sheep passaged BSE transmitting to humans.
Project Documents
• Final Report : Final Report -SE1439   (2750k)
Time-Scale and Cost
From: 2001

To: 2006

Cost: £1,153,100
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Health              
Bio-assay              
BSE              
Plants and Animals              
Sheep              
Transgenic              
Transmission              
TSEs              
Fields of Study
Animal Health