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Disabling neuropsychiatric disease in farmers exposed to organophosphates - VM02115

Description
The chronic effects of low dose exposure to organophosphates are poorly defined in comparison with effects arising from acute exposures. A farmers’ cohort study is thus proposed to examine whether long term exposure to organophosphates may result in potentially disabling neurological or psychiatric illness. The cumulative incidence of dementia, adult onset neurological disease and clinical depression will be measured to determine the excess, if any, after exposure to organophosphates, particularly when subjects with a history of acute poisoning are excluded from the analysis. A nested case-referent study will then be undertaken to determine whether identified cases of dementia, neurological disease or depression differ in exposure to organophosphates than referents matched on age, sex and geographic locality. This study will help to establish whether or not chronic neuropsychiatric disease is indeed a hazard of repeated organophosphate exposure even in the absence of apparent acute poisoning. Estimation of the size of any risk in relation to exposure would permit a more accurate evaluation of the human costs and benefits of organophosphate use and of the possibilities of prevention.
Objective
The objectives of the farmers cohort study are 1. To determine the cumulative incidence of dementia, adult onset neurological disease and clinical depression in farmers2. To establish whether an excess of such disease is apparent in those exposed to organophosphates3. To estimate the size of the excess when subjects with a history of acute poisoning are excluded from the analysisA nested case-referent study will have the additional objective4. determine whether diagnosed cases of dementia, neurological disease or depression differ in their exposure to organophosphates than referents matched on age, sex and geographic locality
Project Documents
• Final Report : Disabling neuropsychiatric disease in farmers exposed to organophosphates Phase 1   (988k)
• Final Report : Disabling neuropsychiatric disease in farmers exposed to organophosphates Phase 2   (1498k)
Time-Scale and Cost
From: 2002

To: 2008

Cost: £448,222
Contractor / Funded Organisations
University - Manchester
Keywords
Animal Health              
Organophosphates              
Plants and Animals              
Veterinary Medicines              
Fields of Study
Animal Health
Veterinary Medicine