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The effects of dietary vitamin supplementation on oxidative low density lipoprotein damage in disease - AN0409

Description
Oxygen derived free radicals (OFR) have been implicated in the pathogensesis of atheriosclerosis and diabetic angiopathic complications. Oxidative modification of low density lipoprotein (LDL) initiated by lipid peroxidation, consumes intrinsic vitamin E and specifically alters essential lysine residues on the glycoprotein apolipoprotein B, therby restricting normal receptor mediated endocytosis and generating a more atherogenic form of LDL. Oxygen toxicity is influenced by the presence of dietary vitamins, heavy metals, antioxidants and polyunsaturated fatty acids, therefore we propose to examine the effects of dietary vitamin supplementation on oxidative damage to LDL. Simultaneous HPLC measurement of vitamins A and E, reduced and oxidised vitamin C and total plasma antioxidant capacity will be correlated with levels of oxidatively modified LDL in subjects that have received combinations of/or individual antioxidant vitamins in a controlled double blind study.
Objective
To establish whether a relationship exists between anti-oxidant nutrients and free radical mediated damage to LDL components in vascular disease.
Time-Scale and Cost
From: 1992

To: 1994

Cost: £81,492
Contractor / Funded Organisations
University - Leicester
Keywords