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Posible strain differences between Swiss and British BSE - SE1767

Description
While there are many different strains of scrapie, there appears to be only one strain of BSE, which produces a characteristic pattern of disease in mice that is retained upon passage through other species. However most strain typing experiments so far were performed with British BSE isolates, and it cannot be excluded that BSE from other countries show different features. Our preliminary results of inoculation experiments indicate a surprisingly high susceptibility of wild-type mice to Swiss BSE. Therefore a thorough comparison of the strain characteristics of Swiss and British BSE will be very instructive. We propose to inoculate different non-transgenic and transgenic mouse strains with Swiss and British BSE. The incubation times, neuropathological changes and glycoform patterns will be determined.
Project Documents
• Final Report : Possible strain differences between Swiss and British BSE   (29k)
• Final Report - Annex : Possible strain differences between Swiss and British BSE   (662k)
Time-Scale and Cost
From: 2001

To: 2003

Cost: £279,249
Contractor / Funded Organisations
UniversitaetsSpital Zurich
Keywords
Animal Health              
Biotechnology              
BSE              
Diagnosis              
Plants and Animals              
Transgenic              
TSEs              
Fields of Study
Animal Health